中文摘要：

成长证据建议导出 myeloid 的 suppressor 房间(MDSC ) 它被称为鈥渋m 成熟 myeloid 房间鈥 ? 或鈥渕y eloid suppressor 房间鈥 ?(MSC ) ，在忍受肿瘤的老鼠和癌症病人在癌症的前进期间起一个关键作用。当他们的名字暗示，这些房间从骨头髓被导出并且有一个巨大的潜力压制有免疫力的回答。最近的研究显示这些房间也在肿瘤前进有一个关键角色。MDSC 能直接把内皮细胞层合并到肿瘤。他们秘密许多 pro-angiogenic 因素也。另外，他们通过导致矩阵 metalloproteinases (MMP ) 的生产在癌症侵略和转移起一个必要作用， chemoattractants 并且创造 pre 变形的环境。增加的证据支持癌症干细胞(CSC ) 为 tumorigenesis，到治疗的抵抗，侵略和转移负责的想法。这里，我们假设那 CSC 可以用作其他的壁龛房间的鈥渉i 杰克鈥 ? MDSC，导致 stemness 和提高的化疗和放射疗法抵抗的维护。直接指向到 MDSC 的反措施可能是有用的为对从侵略和转移的 angiogenesis 和阻止的癌症。因此， MDSC 的学习是重要的理解肿瘤前进并且对癌症提高治疗学的功效。

英文摘要：

Growing evidence suggests that myeloid-derived suppressor cells （MDSCs）,which have been named ＂immature myeloid cells＂ or ＂myeloid suppressor cells＂ （MSCs）,play a critical role during the progression of cancer in tumor-bearing mice and cancer patients.As their name implies,these cells are derived from bone marrow and have a tremendous potential to suppress immune responses.Recent studies indicated that these cells also have a crucial role in tumor progression.MDSCs can directly incorporate into tumor endothelium.They secret many pro-angiogenic factors as well.In addition,they play an essential role in cancer invasion and metastasis through inducing the production of matrix metalloproteinases （MMPs）,chemoattractants and creating a pre-metastatic environment.Increasing evidence supports the idea that cancer stem cells （CSCs） are responsible for tumorigenesis,resistance to therapies,invasion and metastasis.Here,we hypothesize that CSCs may ＂hijack＂ MDSCs for use as alternative niche cells,leading to the maintenance of stemness and enhanced chemo-and radio-therapy resistance.The countermeasure that directly targets to MDSCs may be useful for against angiogenesis and preventing cancer from invasion and metastasis.Therefore,the study of MDSCs is important to understand tumor progression and to enhance the therapeutic efficacy against cancer.