中文摘要：

目的：探讨鼻咽癌放射治疗患者继发真菌感染的影响因素及干预对策。方法对2010年6月至2013年6月接受放射治疗的290例鼻咽癌患者的临床资料进行回顾性分析，比较不同因素对真菌感染的影响。结果290例患者中，74例发生真菌感染，感染菌种以白色假丝酵母菌为主。使用3种及其以上抗菌药物治疗、抗菌药物使用时间大于或等于35 d、使用头孢类抗菌药物可导致真菌感染率升高（ P＜0．05）。患者年龄大于60岁、存在2种以上合并症、有皮肤或黏膜损伤、免疫抑制剂治疗、住院时间大于或等于50 d、接受侵入性诊疗操作、采用常规放射治疗等，均为诱发真菌感染的危险因素（P＜0．05）。结论鼻咽癌放疗患者真菌感染存在多种危险因素。严格控制各种危险因素对预防真菌感染至关重要。

英文摘要：

Objective To investigate the influencing factors of fungal infections in patients with nasopharynge-al carcinoma after radiotherapy .Methods Clinical data of 290 patients with nasopharyngeal carcinoma ,treated with radiotherapy during Jun .2010 and Jun .2013 ,were retrospectively analyzed to identify related influencing factors of fungal infections .Results Among all of the 290 patients ,74 cases were with fungal infections ,mainly of which were caused by Candida albicans .Using antibiotics for at least 35 d ,using at least 3 species of antibiotics and using of ceph-alosporin antimicrobial drugs might increase the incidence rate of fungal infections （P〈0 .05） .Fungal infection might be related to age of patients （more than 60 years） ,skin or mucosal ulceration ,using of immunosuppressive drugs , hospitalization time of at least 50 d ,invasive procedures and conventional radiotherapy （P〈0 .05） .Conclusion Fun-gal infections in patients with nasopharyngeal carcinoma after radiotherapy might be related to various factors .Effec-tive controlling of these factors could be important to prevent fungal infections .