中文摘要：

目的探讨应用核平滑的半参数模型处理重复测量资料。方法利用核平滑和带约束的最小二乘法估计参数,并采用Bootstrap建立可信区间。结果用Matlab程序应用模拟数据得到相应结果。结论核平滑半参数模型可作为处理重复测量资料的一种方法。

英文摘要：

Objective To apply kernel smoothing semiparametric models for repeated measurement data. Methods Estimated the parameters, nonparameters using kernel function and least squares estimate with constrained condition, finally obtained confidence interval by bootstrap methods. Results Applied our method to simulated data, and get desirable results. Conclusion Kernel smoothing semiparametric models is a simply method to process repeated measurement data.