中文摘要：

为了探讨白芍（Radix paeoniae Alba）提取物对MPTP（1-甲基-4-苯基-1,2,3,6-四氢吡啶）致帕金森病小鼠的保护作用,试验采用不同剂量的白芍提取物（0.75、1.50、3.00 g生药/kg体重）灌喂小鼠,每日一次,连续15 d。第八天起所有小鼠每日腹腔注射MPTP 1次共8次,建立小鼠帕金森病（Parkinson’s disease,PD）模型,通过检测小鼠的自主活动、爬杆能力、滚轴能力及悬挂能力等行为学表现,同时检测小鼠脑黑质中超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-Px）活性及丙二醛（MDA）水平的变化来评价白芍提取物对PD小鼠的影响。结果显示,经MPTP诱导的小鼠,其自主活动次数显著减少、爬杆时间差值显著增加、附着能力评分显著降低;经高剂量白芍提取物预处理后能显著（P〈0.05）增加小鼠在测试时间内的自发站立次数,显著（P〈0.05）缩短爬杆时间差值,显著（P〈0.05）提高附着能力分值,极显著（P〈0.01）提高小鼠脑内SOD、GSH-Px水平,MDA水平极显著（P〈0.01）。

英文摘要：

For studying the neuroprotective effect of Radix paeoniae Alba extracts against MPTP-induced mouse model of Parkinson＇s disease（PD） and its mechanism, 60 mice were randomly indiveded to 6 groups, such as nomal control group,model conrol group, positive medicine control group, and three trial groups which treated with Radix Paeoniae Alba extracts of different dots（0.75、1.50、3.00 g/kg,i.g.） for 15 days. At the 8th day, the mice except of the nomal control group were started intraperitoneal injection with MPTP（3.00 g/kg,i.p.） for eight days and the subsequent behavioral testing of mice, such as voluntory movement, rotarod test, pole test and traction test was assessed. SOD、GSH-Px and MDA levels in mouse striatum nigra were measured using analysis Kit. The results showed that the MPTP-induced mice presented typical Parkinson ＇s disease such as voluntory movement significantly decreased, the time difference of climbing pole, significantly increased and the adherence ability assessment significantly decreased, etc. But after pretreated Radix paeoniae Alba extracts, the abnormal behavior including the decrease in spontaneous motor activity and the prolongation in the pole test latent period induced by MPTP were all significantly improved（P〈0.05）.In addition, Radix Paeoniae Alba extracts significantly inhibited the oxidative stress level, such as decreased the level of MDA（P〈0.01） and increased the antioxidant enzyme GSH-Px（P〈0.05） and SOD activity（P〈0.05）.