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中文摘要：
采用化学方法在18β-甘草次酸A环上进行结构修饰,合成了一系列新颖的A环具有不同官能团的开环衍生物.初步研究了它们对人体肝癌细胞HepG-2的体外细胞毒活性,结果表明,羟基的数目和位置对抑制HepG-2细胞增殖起着重要的作用.
英文摘要：
Glycyrrhetinic acid,a facile pentacyclic triterpenoid with rigid and chiral structures,is widely present in the form of aglycone or glycosides in medicinal plants,which is used as bioactive component on anti-inflammatory,anti-viral and anti-tumor-promotion effect. Owing to its relative low-toxicity,biocompatibility and bioactivity,a series of novel opened A-ring and different functional group derivatives of glycyrrhetinic acid was synthesized by chemical methods. The preliminary biological activities were tested against human liver carcinoma（ HepG-2） cell in vitro. The results show that the activity should be affected by the number and the position of hydroxyls.
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Hu J, Lu JR, Li RF, Ju Y*, Synthesis and Self-Assembly Properties of A Glycyrrhetinic Acid Conjugate
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Poly(p-phenylene ethynylene)s with Facially Amphiphilic Pendant Groups: Solvatochromism and Supramol
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