中文摘要：

microRNA（miRNA）是近年来发现的-类长度为18—25个核苷酸的非编码小分子单链RNA。它主要通过与靶标基因3’UTR（非翻译区）的完全或不完全配对，降解靶标基因mRNA或抑制其翻译，从而参与调控个体发育、细胞凋亡、增殖及分化等生命活动。越来越多的实验证据表明，miRNA可通过调控其靶标基因参与的信号通路，影响肿瘤的发生和发展，发挥类似于癌基因或抑癌基因的功能。miRNA的发现为肿瘤发病机制的研究提供了新思路，也为肿瘤诊断和治疗提供了新的策略。本综述主要介绍miRNA-130a与非小细胞肺癌（non～small cell lung cancinoma，NSCLC）侵袭转移相关研究进展。

英文摘要：

miRNAs are a species of small noncoding single - stranded RNAs of approximately 18 to 25 nucleotides, which inhibit the expression of protein -coding genes by binding to the 3UTR （untranslated region） of mRNAs and inducing either translational repression or mRNA degradation, and then miRNAs regulate a wide range of biologieaJ processe, including development, cell differentiation, proliferation and apoptosis. Growing evidences have indicated that miRNAs exert their tumor suppressor or oncogenie function by regulating the signaling pathways. Characterization of miRNA provides us a new insight into the molecular mechanisms underlying tumorigenesis as well as the new strategy for cancer diagnosis and treatment. This review summarizes the recent progression on the research field of miRNA - 130a and its association with tumor invasion and metastasis.