中文摘要：

某些革兰阴性菌是临床感染的重要病原菌,面对越来越严重的耐药菌威胁,多黏菌素已经成为临床抗多药耐药革兰阴性菌病原菌的最后一道防线。革兰阴性菌中脂质A的修饰可以造成细菌表面电负性的变化,进而造成对于多黏菌素的耐药,该文综述了铜绿假单胞菌、鲍曼不动杆菌、肺炎克雷伯菌、沙门氏菌和弗朗西斯菌等重要革兰阴性菌中,脂质A修饰的研究进展,以期为临床多黏菌素耐药机制及其相关药物的开发提供参考。

英文摘要：

The gram-negative bacteria were important pathogenic bacteria in clinical infection. Polymyxin would be the last defence against multi-resistant gram negative pathogenic bacteria. The Lipid A modification of gram negative pathogenic bacteria can change the electronegativity of bacterial cell surface and lead to polymycin resistance. Here the research advances of the Lipid A modification of several important gram-negative pathogenic bacteria （ P. aeruginosa, A. baumannii, P. klebsiella, Salmonella and Francisella tularensis） were reviewed. It will provide a valuable reference for polymyxin resistant mechanism researches and the development of related drugs.