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基于道地药材标准的炮制苍术挥发油变化规律研究
  • ISSN号:1001-2494
  • 期刊名称:中国药学杂志
  • 时间:0
  • 页码:1750-1753
  • 语言:中文
  • 分类:R284[医药卫生—中药学;医药卫生—中医学]
  • 作者机构:[1]中国中医科学院中药研究所,北京100700, [2]山东中医药大学,济南250014
  • 相关基金:国家自然科学基金资助项日(30672616,30672617);国家科技支撑计划(2006BAl09803);国家重点基础研究发展计划(2006CB504700)
  • 相关项目:环境胁迫下AM影响苍术质量的机理研究
中文摘要:

目的分析麸炒苍术挥发油成分的变化,阐述将道地药材标准用于苍术炮制品质量分析的可行性。方法在过去对道地药材苍术(产地江苏茅山)已有研究的基础上,取10株非道地产区苍术(产地湖北英山)根茎分单株进行炮制,采用GC—MS分离鉴定挥发油中各成分,使用SPSS10.0分析软件,进行,检验和聚类分析。结果,检验分析显示,麸炒后苍术总挥发油含量较生品显著降低(P〈0.05),其归一化百分含量大于1%的组分数目明显高于麸炒前(P〈0.05)。麸炒前后分离出共有成分18种,其中2种成分麸炒后含量显著低于麸炒前(P〈O.05);9种成分麸炒前后无显著性差异(P〉0.05);7种成分麸炒后显著高于麸炒前(P〈0.05);麸炒后新增加的成分7种。聚类分析结果显示,麸炒前后苍术挥发油成分表现出一定的差异性。结论炮制后苍术总挥发油含量降低,尤其是β-桉叶醇、茅术醇含量低,挥发油组分数目显著增多,较生品更为接近道地药材,用道地药材标准来探讨苍术炮制品质量具有一定可行性。

英文摘要:

OBJECTIVE To analyze the changes of naphtha components ofAtractylodes lancea stirred-frying with bran, and to elucidate the feasibility of the application of geoherbs standardization for quality analysis of processed Atractylodes lancea. METHODS On the basis of previous study of geoherbs ofAtractylodes lancea, 10 rhizomes ofAtractylodes lancea from Hubei Yingshan were processed, and naphtha components were determined by GC-MS. t-test and Custer Analysis were carried out by SPSS10.0. RESULTS t-test analysis indicated that the general oil of processed Atractylodes lancea was lower than that of non-processed Atractylodes lancea (P〈0.05), but components yielding more than 1% (1% of the total oil) were more than that of non-processed samples (P〈0.05). 18 Components isolated and determined from the oil of processed and non-processed Atractylodes lancea. The contents of 2 components were decreased (P〈0.05) after being processed, 9 components remained unchanged (P〉0.05), and the other seven components increased (P〈0.05). 7 components increased after being processed. The changes of naphtha components of processed and non-processed Atrac(ylodes lancea were determined by a cluster analysis. CONCLUSION The content of total oil decreased after being processed, especially the contents offl-eudesmol and hinesol, but the number of the components increased, which indicated that processed Atractylodes lancea was closer to geoherbs than the non-processed ones. Consequently, it is feasible to evaluate the quality of processed Atractylodes lancea by geoherbs standardization.

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期刊信息
  • 《中国药学杂志》
  • 中国科技核心期刊
  • 主管单位:中国科学技术协会
  • 主办单位:中国药学会
  • 主编:桑国卫
  • 地址:北京市朝阳区建外大街四号建外SOHO九号楼18层
  • 邮编:100022
  • 邮箱:zgyxzz@cpa.org.cn
  • 电话:010-58698009
  • 国际标准刊号:ISSN:1001-2494
  • 国内统一刊号:ISSN:11-2162/R
  • 邮发代号:2-232
  • 获奖情况:
  • 首届国家期刊奖,第一、二届全国优秀科技期刊一等奖,中国期刊方阵“双高”期刊
  • 国内外数据库收录:
  • 美国国际药学文摘,美国化学文摘(网络版),荷兰文摘与引文数据库,荷兰医学文摘,日本日本科学技术振兴机构数据库,中国中国科技核心期刊,中国北大核心期刊(2004版),中国北大核心期刊(2008版),中国北大核心期刊(2011版),中国北大核心期刊(2014版),英国英国皇家化学学会文摘,中国北大核心期刊(2000版)
  • 被引量:54982