中文摘要：

替米考星按20mg／kg剂量经灌胃给药后，观察其对内毒素（LPS）炎症小鼠的保护率，并通过不同时间段眼球采血，分离血清，应用试剂盒用酶联免疫吸附分析（Enzyme-linked immunosorbent assy，ELISA）法测定小鼠血清中肿瘤坏死因子-α（TNF—α）、白细胞介素-10（IL-10）、白细胞介素-6（IL-6）、白细胞介素-1（IL-1β）的水平。结果表明，替米考星明显提高了内毒素炎症小鼠的存活率，死亡率由100%降低为50％（P〈0．05）。LPS（20mg／kg）能提高血清中TNF-α、IL-10、IL-6和1L-1β的水平，替米考星能够显著抑制TNF-α、IL-6和IL-1β的释放，而明显提高IL-10的水平。

英文摘要：

The inflammation mice model was established by intraperitoneal injection of LPS（20 mg/kg）,and administered the tilmicosin （20 mg/kg） by gavage. The results showed the tilmieosin remarkably improved the survival rate of mice challenged with LPS. Compared with LPS group at 24 hour,the mortality of timilcosin group obviously dropped from 100% to 50% （P〈0.05）. There was a distinct decrease in serou TNF -α,IL-10,IL -6 and IL-1β contents and increase in serou IL- 10 levels in tilmicosin group compared with LPS group.