HBV感染人体后的临床表现与机体免疫功能状态密切相关,而人类白细胞抗原(HLA)Ⅰ类基因复合体的表达产物直接调控机体免疫状态,这就造成HBV感染后结局与宿主的HLA基因多态性相互关联。此文主要介绍HLA-Ⅰ基因多态性与乙型肝炎发生发展与预防的关系。
The outcome of HBV infection mainly depends on the host immune response, and human leukocyte antigen (HLA) class I molecules are associated with host immune responses against hepatitis B virus infection. This paper introduces the relationship of HLA- I gene and the prevention, occurrence, development of hepatitis B.