中文摘要：

骨形态发生蛋白-2（BMP-2）属于TGF-β（β转化生长因子超家族），是目前成骨活性最强、研究最广泛的骨生长因子。BMP-2等外源性生长因子稳定性不好、体内半衰期短，需要大剂量、多次应用，因此，研究BMP-2的缓释方法具有重要意义。本文对BMP-2的促骨再生作用、不同类型的BMP-2缓释载体及其选择原则、不同类型的缓释材料的研究及其他较为新颖的BMP-2缓释材料的研究等进行综述，提出研发生物相容性更好、栽药率更高的可降解的新型载体等将是未来研究的重点方向。

英文摘要：

Bone morphogenetic protein -2 （ BMP-2 ）, which belongs to the TGF-beta （ transforming growth factor beta）, is the most active and widely studied bone growth factor. BMP-2 is volatile and short in terms of its half-life in vivo, so it has to be applied in large doses and for multiple times. Therefore, the study of sustained release of BMP-2 is of great significance. In this paper, the role of BMP-2 in promoting bone regeneration, different types of sustained release carriers and their selec- tion principles,study of the sustained-release materials of different forms and other relatively new BMP-2 sustained-release materials research are summarized. It is the key direction of future research to develop a new biodegradable carrier material with better biocompatibility and higher drug loading rate.