中文摘要：

黄连素是从黄连、黄柏等植物中提取出来的一种生物碱,其具有显著的抗菌作用,用来治疗细菌性胃肠炎、痢疾等消化道疾病已有很长的历史。近年来,黄连素的其他药理作用逐渐被发现。研究结果表明,黄连素对心血管系统、神经系统、内分泌系统等均有明显影响,尤其是降血脂作用对防治动脉粥样硬化效果良好。黄连素还能增加胰岛素的敏感性来治疗糖尿病。黄连素被发现有明显的抗炎抗癌作用。黄连素能杀伤肿瘤细胞抑制肿瘤细胞增殖和诱导肿瘤细胞的凋亡。黄连素还能影响钙离子、钾离子等离子通道来调节电解质平衡。由于黄连素的抗炎抗氧化作用,可用于治疗消化性溃疡。本文就黄连素的作用及其机制进行了详细的总结,包括黄连素对心血管系统、神经系统、内分泌系统的影响以及抗炎、抗菌、抗癌等药理作用,还有对离子通道、周期蛋白、细胞外基质的影响。有关黄连素的作用及机制越来越引人关注,尤其是抗癌活性,表明对含有黄连素这一活性成分的中药及方剂的研究将会有新的进展。总结黄连素的作用及其机制,将有助于提高黄连素的临床应用及新药研发。

英文摘要：

Berberine,extracted from Coptis chinensis,Phellodendron amurense and other herbs,is a kind of alkaloid with significant antibacterial effects. Ithas been used in the treatment of bacterial gastroenteritis,dysentery and other gastrointestinal diseases for a long time. In recent years,other pharmacological activities of berberine have beengradually discovered. The studies have shown that berberine has significant effects on the cardiovascular system,nervous system,endocrine system,especially effective for the prevention and treatment of atherosclerosis,and berberine can also increase the sensitivity of insulin to treat diabetes. In addition,it is found that berberine has anti-inflammatory actions and anti-cancer effects. Berberine can kill tumor cells, inhibit proliferation of tumor cells and induce apoptosis of tumor cells. Berberine can also affect the ion channels of biomembrane such as calcium ion and potassium ion to adjust the electrolyte balance. Because of the antiinflammatory and anti-oxidation actions,it is also used to treat peptic ulcer. In this report,the actions and mechanism of berberine were summed up,including the effects of berberine on the cardiovascular system,nervous system,endocrine system and the pharmacological effects of anti-inflammatory,anti-bacterial,and anti-cancer actions,as well as its effects onion channels,cyclin,and extracellular matrix. The actions and mechanism of berberine have obtained more and more attention,especially anti-cancer effects,indicating there will be new progress in the study on traditional Chinese medicines and prescriptions containing berberine. The summary of actions and mechanism of berberine would be helpful to improve the clinical applicationsof berberineand RD of new drugs.