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中文摘要：
通过2-芳亚甲基-6，7-二氢-5H-噻唑并[3，2-α]日嘧啶-3-酮（1a-1j）与甲亚胺叶立德（经靛红与肌氨酸反应原位生成）进行的1，3-偶极环加成反应，合成了10个新的螺噻唑并[3，2-α]嘧啶类化合物2a-2j．采用NMR、质谱、IR、元素分析以及X射线单晶衍射等多种谱学技术对产物2a-2j进行了结构表征，研究结果表明此类反应具有高度的立体选择性和区域选择性．
英文摘要：
A new class of spiro thiazolo[3,2-α]pyrimidine compounds 2a-2j were synthesized by the 1,3-dipolar cycloaddition reaction of 2-arylmethylidene-6,7-dihydro-SH-thiazolo[3,2-α]pyrimidin-3-one （1a-1j） with azomethine ylide （generated in situ by the reaction of isatin with sarcosine）. The structures of the products 2a-2j were determined and characterized thoroughly by NMR, MS, IR techniques, elemental analysis, and X-ray crystallographic analysis. The results of experiment indicated that this 1,3-dipolar cycloaddition proceeded with high stereoselectivity and regioselectivity.
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