中文摘要：

多重骨髓瘤(公里) 是说明 13% 所有 hematologic 癌症的严重地区分的 B 淋巴细胞的恶意。尽管有在治疗学象重要进展一样描述公里的分子的生物学的很多知识，这疾病仍然保持医不好。因为蛋白质管理细胞的结构和生物功能，大量精选的 proteomic 为增加我们这疾病的理解接近抓住伟人诺言，例如由调查蛋白质表示的动态性质，细胞并且在两个的 subcellular 分发， translational 以后修正，和相互作用细胞并且 subcellular 层次。这评论的目的是介绍在公里的学习有潜在的应用的可得到、新兴的 proteomic 技术并且加亮公里的 proteomic 研究的当前的地位。迄今为止，尽管在公里有一小部分 proteomic 研究，执行的那些关于公里诊断和治疗提供了珍贵信息。proteomic 技术的潜在的未来申请被期望为临床医生在公里诊断，个性化的治疗设计和治疗反应监视提供新大街。

英文摘要：

Multiple myeloma （MM） is a malignancy of terminally differentiated B-lymphocytes that accounts for -13% of all hematologic cancers. Despite a wealth of knowledge describing the molecular biology of MM as well as significant advances in therapeutics, this disease remains incurable. Since proteins govern the cellular structure and biological function, a wide selection of proteomic approaches holds great promise for increasing our understanding of this disease, such as by investigating the dynamic nature of protein expression, cellular and subcellular distribution, post-translational modifications, and interactions at both the cellular and subcellular levels. The aims of this review are to introduce the available and emerging proteomic technologies that have potential applications in the study of MM and to highlight the current status of proteomic studies of MM. To date, although there have been a limited number of proteomic studies in MM, those performed have provided valuable information with regard to MM diagnosis and therapy. The potential future application of proteomic technologies is expected to provide new avenues in MM diagnostics, individualized therapy design and therapy response surveillance for the clinician.