中文摘要：

SOCS1 是 cytokine 发信号的一个关键管理者并且为在免疫系统维持平衡是重要的。在 cytokine 发信号参予否定反馈环被认为并且可以是为树枝状的房间(DC ) 的规定的一个重要信号成熟。然而，它仍然保持不清楚是否有规章的 DC 的 SOCS1 展览特征的 DC transduced 并且导致 allogeneic T 房间 hyporesponsiveness。在这研究，我们构造了编码能高效地在骨头增加 SOCS1 基因表示的 SOCS1 (Ad-SOCS1 ) 的 adenoviral 向量导出髓的树枝状的房间。有 Ad-SOCS1 (DC-SOCS1 ) 的 DC transduced 表示了 costimulatory 和 MHC 分子的底层，对成熟和激活刺激抵抗，导致了 allogeneic T 房间 hyporesponsiveness，并且支持了在 vitro 的象规章一样 T 房间的产生。DC-SOCS1 预告的处理显著地延长了 allografts 的幸存并且在规章的 T 房间的产生导致了实质的增加。我们的数据建议 SOCS1 禁止 DC 成熟并且导致规章的 DC 产生，因此拥有治疗学的潜力在机关移植阻止拒绝。

英文摘要：

SOCS1 is a key regulator of cytokine signaling and is important for maintaining balance in the immune system. It is thought to participate in negative feedback loops in cytokine signaling and may be an important signal for the regulation of dendritic cell （DC） maturation. However, it remains unclear whether DCs transduced with SOCS1 exhibit characteristics of regulatory DCs and induce allogeneic T-cell hyporesponsiveness. In this study, we constructed adenovirai vector coding SOCS1 （Ad-SOCS1） that can efficiently increase SOCS1 gene expression in bone marrow-derived dendritic cells. DCs transduced with Ad-SOCS1 （DC-SOCS1） expressed low levels of costimulatory and MHC molecules, were resistant to maturation and activation stimulation, induced allogeneic T-cell hyporesponsiveness, and promoted the generation of regulatory-like T cells in vitro. DC-SOCS1 pretreatment significantly prolonged the survival of ailografts and led to a substantial increase in the generation of regulatory T cells. Our data suggest that SOCS1 inhibits DC maturation and induces regulatory DC generation, therefore possessing therapeutic potential to prevent rejection in organ transplantation.