中文摘要：

以商品化的R-香茅醇为原料,经Julia-Lythgoe反应和Sharpless不对称双羟化等15步反应,以7.6%的总收率建立了天然产物Leiodelide A的关键片段19的合成方法,所有的中间体结构均经1H NMR,13C NMR和ESI-MS确证.

英文摘要：

An enantioselective route for compound 19, a key fragment toward the asymmetric synthesis of leiodelide A, is described. This key compound 19 was synthesized through Julia-Lythgoe olefination and Sharpless asymmetric dihydroxylation in 7.6% overall yield. All intermediates were characterized by ~1H NMR,~（13） C NMR and ESI-MS spectral data.