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茵陈蒿汤肝细胞结合成分对肿瘤细胞的影响
  • 期刊名称:中药药理与临床
  • 时间:0
  • 页码:96-98
  • 分类:R289.5[医药卫生—方剂学;医药卫生—中药学;医药卫生—中医学]
  • 作者机构:[1]南京中医药大学药学院,南京210029
  • 相关基金:国家自然科学基金资助项目30300446 30902014; 江苏省高校自然科学基金资助项目03KJB360094 09KJB360001; 南京中医药大学青年基金项目:09XZR23资助
  • 相关项目:雌激素受体靶向的细胞固相化萃取机制研究
中文摘要:

目的:观察茵陈蒿汤细胞膜固相化色谱法特异性结合成分对肿瘤细胞的影响。方法:采用MTT法测定不同浓度的细胞膜固相色谱法得到的与肝细胞特异性结合的活性成分(样品A、B、C、D、E)对SMMC-7721人肝癌细胞及A549人肺癌细胞活力的影响,观察药物对癌细胞增殖的影响。结果:样品A、C、E能显著抑制SMMC-7721人肝癌细胞的增殖,样品A、B、C对人肺癌细胞A549具有显著抑制作用。结论:样品A、B、C、E可能是茵陈蒿汤抗肿瘤作用的活性成份。

英文摘要:

Objective: To investigate the effects of the chemicals from Yinchenhao Decoction which specifically bind to hepatocytes on tumor cells.Methods: SMMC-7721 human hepatocellular carcinoma cells and A549 human lung carcinoma cells were used in this experiment.Cells were exposed to chemicals from Yinchenhao Decoction which specifically bind to hepatocytes(sample A,B,C,D,E).The proliferation of tumor cells were evaluated after 48h by MTT assays.Results: Sample A,C,E significantly inhibited SMMC-7721 cell proliferation.and sample A,B,C significantly inhibited A549 cell proliferation.Conclusion: Sample A,B,C,E maybe antitumor effective components of Yinchenhao Decoction.

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