中文摘要：

随着人们对肿瘤发病机制认识水平的不断深入，DNA加合物的研究也越来越受到重视。PAH-DNA加合物是一种暴露标记物，在生物监测和流行病学研究中有重要意义。本文总结了PAH—DNA加合物与职业暴露、环境污染及其代谢酶、修复酶基因多态性的关系，并介绍了目前常用于检测PAH—DNA加合物的几种方法。

英文摘要：

With the deepening research on etiology mechanism of tumour, people pay more and more attention to DNA adducts. Polycyclic Aromatic Hydrocarbon-DNA （PAH-DNA） Adducts, as exposure biomarkers, have great significance for surveillance and molecular epidemiology. The article summarizes relations between PAH-DNA adducts, occupational exposure, environmental pollution and polymorphism of metabolizable enzyme and repair enzyme, and introduces methods of testing PAH-DNA adducts.