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中文摘要：
应用荧光加强和荧光猝灭两种理论公式，对四种喹诺酮类药物与人血清和牛血清白蛋白的作用作进行了对比研究，对药物与白蛋白的结合特点和通常的表征量（解离常数、猝灭常数、猝灭效率、能量转移效率、给体-受体作用距离等）进行了深入地分析；在白蛋白与药物结合类型上，四种药物对HSA和BSA的猝灭实验结果表明，这种由给体-受体结合引起的猝灭作用类型不是由生物大分子血清白蛋白单方面决定的，而是由血清白蛋白与药物、即给体与受体两者的分子结构和相互匹配共同决定的．
英文摘要：
By using the two theories fluorescence enhancement and fluorescence quenching, we studied and compared the inter action of four kinds of Quinolone-class-medicines with HSA and BSA, then analysed deeply the binding speciality of medicine and albumin and usual characterization constants： dissociation constant, quenching constant, quenching efficiency, energy-transfer efficiency, the distance between donor and accepter. About binding type of albumin with medicine, through the quenching experiment result of the four kinds of medicines with HSA and BSA, we found that this quenching action type caused by the binding of donor between acceptor was not determined by the oneself-biomacromolecule BSA, but together determined by the molecular structure of BSA and medicine, donor and acceptor, and their match with each other.
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