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中文摘要：
[目的]探讨HBV前S1抗原和乙肝“两对半”组合模式的关系及其临床意义。[方法]采用ELISA双抗体夹心法对222例共4种乙肝“两对半”常见组合模式的HBsAg阳性血清和80例HBsAg阴性的血清进行前S1抗原检测，并对检测结果进行比较分析。[结果]HBsAg阳性血清222份，前S1抗原检出80例（36．04％）。其中HBeAg阳性86例，前S1抗原检出47例（54．65％），HBeAg阴性136例，前S1抗原检出33例（24．26％），两者差异有统计学意义（x^2=21．10，P〈0．01）。HBsAg阴性血清中未检出前S1抗原。[结论]前S1抗原与HBeAg具有较好的相关性，是HBV复制的可靠指标之一，与乙肝“两对半”联合检测可更准确反映HBV感染复制状况。
英文摘要：
[Objective] To discuss the relationship of Pre-s1 with other hepatitis B virus serum markers and their clinical significance. [ Methods] Pre-s1 were detected by ELISA in 222 serums of cases with HBsAg positive and 80 serums of cases with HBsAg negative. [Results] In 222 HBsAg positive serums, positive Pre-s1 were found in 47 serums out of 86 HBeAg positive serums （54.65%） and in 33 serums out of 136 HBeAg negative serums （24.26%） .The ratio of positive Pre-s1 in HBeAg positive serums was significantly higher than that in HBeAg negative serums （x^2= 21.10, P 〈 0.01 ） .In HBsAg negative serums, no Pre-s1 was dectected. [ Conclusions] Pre-s1 is a credible index of HBV replication, and may be of help for HBV marker in detecting.
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