中文摘要：

目的利用响应面分析法对大蓟炮制工艺进行优化。方法在单因素实验基础上选取实验因素与水平，根据中心组合（Box—Benhnken）实验设计原理采用三因素三水平的响应面分析法，确定各工艺条件的影响因素，以HPLC测定大蓟黄酮的主要成分变化为响应面和等高线，优选出大蓟炒炭的最佳工艺。结果大蓟炮制的最佳工艺为炮制时间13min、炮制温度（310±10）℃、投药量100g。结论响应面方法是一种有效的统计技术，它是利用实验数据，通过建立数学模型来解决受多种因素影响的最优组合问题，应用于中药炮制工艺优选方面非常有意义。

英文摘要：

OBJECTIVE To optimize the processing technology of Cirsium japonicum DC by response surface methodology （RSM）. METHODS Based on single factor studies, a three-variable, three-level Box-Benhnken experimental design was used to monitor the effects of independent variables like time, temperature, and weight on the dependent variable, yield of flavonoids when Cir- sium japonieum DC were processed. Response surface and contour plots with flavonoids＇ yield as a function were obtained with the help of HPLC. RESULTS The optimum conditions were processing time 13 min, processing temperature （310 ±10） ℃, and raw material weight 100 g. CONCLUSION RSM is an effective technology to optimize the processing traditional Chinese medicine.