中文摘要：

肌肉抑制素Myostatin是TGF-β（transforming growth factor-β）超家族成员之一,在哺乳动物及非哺乳动物中均能够抑制肌细胞的增殖和分化,是骨骼肌生长的负调控因子。但Myostatin基因自身是如何被调控的目前仍然不十分清楚。该实验发现,碱性成纤维细胞生长因子bFGF（basic fi broblast growth factor）能够上调Myostatin的表达。进一步分析表明,bFGF对于Myostatin的表达调控存在剂量和时间依赖性。同时实验还发现,MAPK信号通路部分地介导了bFGF对Myostatin基因的调节作用。

英文摘要：

Myostatin（MSTN）, a member of transforming growth factor-β（TGF-β） superfamily, is a negative regulator of the skeletal muscle growth by suppressing the proliferation and differentiation of myoblast. In this study, MSTN is up-regulated by basic fibroblast growth factor（bFGF） in a dose and time-point dependent manner. Moreover, MAPK signal pathway is found to partially participate in the effect on Myostatin gene expression induced by bFGF.