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中文摘要：
泛素介导的蛋白质降解途径是降解细胞内蛋白质的主要途径，在维持细胞正常的蛋白质代谢中起着至关重要的作用。泛素介导的蛋白质降解途径的异常与许多疾病特别是肿瘤的发生密切相关。通过介绍泛素介导的蛋白质降解途径在细胞周期、DNA修复、细胞凋亡中的作用，系统阐述了泛素介导的蛋白质降解途径与肿瘤发生的关系。
英文摘要：
The ubiquitin-proteasome proteolytic pathway, a major pathway for protein degradation in cells, plays a critical role in the protein metabolism. So abnormality of the ubiquitin-proteasome proteolytic pathway is closely related to many diseases, especially cancer. In this paper ubiquitin-proteasome proteolytic pathways during the cel between these pathways and tumorigenesis. we reviewed the study of the significant role of the cycle, DNA repair and apoptosis, especially the relationship between these pathways and tumorigenesis.
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