中文摘要：

目的检测中国汉族急性白血病（AL）患者和健康受试者中CYP3A4＊18和CYP3A5＊3基因型分布特征,探讨CYP3A4和CYP3A5基因多态性与中国汉族AL易感性的相关性。方法病例对照研究,用聚合酶链反应（PCR）后直接测序的方法,检测中国汉族AL患者91例,健康受试者200例的CYP3A4＊18B和CYP3A5＊3位点的基因型分布及等位基因频率。结果中国汉族AL患者和健康受试者CYP3A4＊18B和CYP3A5＊3基因型分布均符合Hardy-Weinberg平衡。与健康受试者比较,AL患者CYP3A4＊18B基因型及等位基因频率差异均无统计学意义（P〉0.05）,CYP3A5＊3基因型及等位基因分布频率差异均有统计学意义（P〈0.05）。结论 CYP3A4＊18B多态性与中国汉族AL的易感性可能无关,CYP3A5＊3多态性与中国汉族AL的易感性可能相关。

英文摘要：

Objective To detect the frequency distribution patterns of CYP3A4＊ 18B and CYP3A5 ＊ 3 polymorphisms in Chinese Han ethnic healthy volunteers and patients with acute leukemia,and explore the correlation between CYP3A4 and CYP3A5 genetic polymorphisms and the susceptibility of acute leukemia.Methods A case-control study was carried out to compare the distribution of genotypes and genetic frequencies of CYP3A4 ＊ 18B and CYP3A5 ＊ 3 genetic polymorphisms between acute leukemia（n = 91） and healthy volunteers（n = 200） with polymerase chain reaction-direct sequencing method.Results The distribution of genotypes and genetic frequencies of CYP3A4 ＊ 18B and CYP3A5 ＊ 3 were both in accordance with Hardy-Weinberg balances（P〈 0.05）.There was no significant difference in the distribution of genotype of CYP3A4＊ 18B between the healthy volunteers and patients with acute leukemia（P〈 0.05）.But there was a significant difference in the distribution of genotype of CYP3A5＊ 3 between the healthy volunteers and patients with acute leukemia（P〈 0.05）.Conclusion The patients with ＊ 18B allele of CYP3A4 might not be contributed to the susceptibility of acute leukemia,while ＊ 3 allele of CYP3A5 might be contributed to the susceptibility of acute leukemia.