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Molecular Properties of the Epstein-Barr virus BFRF3 Gene

ISSN号：1003-5125
期刊名称：Virologica Sinica
时间：2013.12
页码：368-372
分类：Q785[生物学—分子生物学] S512.1[农业科学—作物学]
作者机构：[1]Department of Pathogenic Biology and Immunology,Guangzhou Medical University, Guangzhou 510182, China, [2]Department of Veterinary Medicine, Foshan Scienceand Technology University, Foshan 528231, China
相关基金：Acknowledgments This work was supported supported by grants from Science andTechnology New Star in Zhu Jiang,Guangzhou City（2013J2200018）; the Natural Science Foundation ofGuangdong Province（S2013040016596）; the National Natural Science Foundation of China（31200120）; the Medical Scientific Research Foundation of Guangdong Province,China（B2012165）; the Foundation for Distinguished Young Talents in Higher Education of Guangdong,China First Batch of Young Core Instructor of Guangzhou Medical University;the Science and Technology Found ationfor Universities in Guangzhou,China（10A173 and08A097）; the Students’ Extracurricular ScientificAnd Technological Activities in Guangzhou Medical University （2012A039 and 2012C007）;We thank Dr.Teru Kanda for the generous gift of Akata-derivedEBV-BAC
相关项目：伪狂犬病毒晚期蛋白UL31亚细胞定位信号的鉴定及其生物学功能的研究

作者： Yalan Chen|Changling Ma|Zhuqing Yuan|Meili Li|

关键词： EPSTEIN-BARR病毒, RF3基因, 分子性质, 生物信息学, 衣壳蛋白, 亚细胞定位, 分子特性, EBV

中文摘要：

<正>Dear Editor,We report the results of cloning,expression,subcellular localization analysis,and molecular properties of the Epstein-Barr virus (EBV) BFRF3 gene,using several bioinformatics tools.Bioinformatics analysis indicated that the encoding protein of EBV BFRF3 gene (designated BFRF3) has a conserved Herpes_capsid domain,which was found to be closely related to the gammaherpesvirus capsid protein family,and is highly conserved among its counterparts.Multiple nucleic acid sequence and amino acid (aa) sequence alignments suggested that BFRF3 has a relatively higher homology

英文摘要：

We report the results of cloning,expression,subcellular localization analysis,and molecular properties of the Epstein-Barr virus （EBV） BFRF3 gene,using several bioinformatics tools.Bioinformatics analysis indicated that the encoding protein of EBV BFRF3 gene （designated BFRF3） has a conserved Herpes_capsid domain,which was found to be closely related to the gammaherpesvirus capsid protein family,and is highly conserved among its counterparts.

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