欢迎您！东篱公司
退出
-
申报数据库
-
立项数据库
-
成果数据库
-
项目获奖数据库
中文摘要：
以5-氨基苯并咪唑酮为原料,经过酰化和取代反应合成了目标化合物,并采用Ellman分光光度法,考察了它们对乙酰胆碱酯酶的体外抑制活性。结果表明部分目标化合物具有一定的乙酰胆碱酯酶抑制活性,其中化合物4d的抑制活性最好,其IC50=7.2μmol·L^-1,优于对照药利斯的明;同时它对丁酰胆碱酯酶几乎没有抑制活性。5-氨基苯并咪唑酮类化合物对乙酰胆碱酯酶的抑制活性值得进一步研究。
英文摘要：
The target compounds were prepared from 5-aminobenzimidazolone by two steps reaction, and their AChE inhibitory activities were measured by Ellman method in vitro. The AChE inhibitory activity of compound 4d is the best of them, and its IC50 value is equal to 7.2 μmol·L^-1, which is better than that of rivastigmine; moreover the 4d had no inhibitory activities to BuChE. Therefore, the inhibitory activities of 5-aminobenzimidazolone derivatives to acetylcholinesterase are worth further researching.
同期刊论文项目
同项目期刊论文
The preparation of a novel organic-inorganic hybrid monolithic column with sonication-assist and its
The fabrication of monolithic capillary column based on poly (bisphenol A epoxy vinyl ester resin-co
Preparation and Characterization of a Novel Porous Cation-Exchange Polymeric Monolith by Atom Transf
ON-LINE ENRICHMENT OF THREE PHENOLIC COMPOUNDS USING A POLY(N-ISOPROPYLACRYLAMIDE-CO-VINYL ESTER RES
Preparation of a novel skeleton porous polymeric monolith by reverse atom transfer radical polymeriz
On-Line Solid-Phase Extraction Based on Poly (NIPAAm-MAA-co-EDMA) monolith coupled with High-perform
On-line simultaneous deproteinization of biological samples and trace enrichment of three dipine ser
Imidazolium embedded C8 based stationary phase for simultaneousreversed-phase/hydrophilicinteraction
Preparation of a novel porous poly (trimethylol propane triacrylate-co-ethylene dimethacrylate) mono
The preparation of a novel organic–inorganic hybrid monolithic column with sonication-assist and its
ON-LINE ENRICHMENT OF THREE PHENOLICCOMPOUNDS USING APOLY(N-ISOPROPYLACRYLAMIDE-CO-VINYLESTER RESIN)
Ionic liquid molecularly imprinted polymers for application inpipette-tip solid-phase extraction cou
Dispersive Solid-Phase Extraction Based on Magnetic Dummy Molecularly Imprinted Microspheres for Sel
A self-assembly pipette tip graphene solid-phase extraction coupled with liquid chromatography for t
Preparation of a novel porous poly(trimethylol propane triacrylate-co-ethylene dimethacrylate) monol
High-performance liquid chromatography separation of smallmolecules on a porous poly (trimethylol pr
Preparation and characterization of poly(triallyl isocyanurate -co-trimethylolpropane triacrylate) m
Preparation of a Novel Skeletal Porous Polymeric Monolith by Reverse Atom Transfer Radical Polymeriz
Preparation of a novel skeleton weak anion-exchange monolith by single electron transfer-living radi
PREPARATION OF A NOVEL HYBRID MONOLITHIC COLUMN BASED ON ATRP OF GMA CATALYZED BY FeCl2/CCl4 AND APP
On-line solid phase extraction using organic-inorganic hybrid monolithic columns for the determinati
A simple and efficient method for preparation of a strong cation exchange monolith and its applicati
Ionic liquid-modified magnetic polymeric microspheres as dispersive solid phase extraction adsorbent
Miniaturized graphene-based pipette tip extraction coupled with liquid chromatography for the determ
Enantioseparations of three amino alcohols using adi-n-butyl- L -tartrate–boric acid complex as them
Fabrication of an ionic liquid-based macroporous polymer monolithic column via atom transfer radical
Incorporation of ionic liquid into porous polymer monoliths to enhance the separation of small molec
Ionic liquid as porogen in the preparation of a polymer-based monolith for the separation of protein
The fabrication of monolithic capillary column based on poly(bisphenolA epoxy vinyl ester resin-co-e
Preparation of a porous functional polymer by a simple method and its application in high performanc
Preparation of a Hybrid Cation-Exchange Monolith and Its Applicationfor the Separation of Proteins b
Preparation of a porous polymer monolithic column with an ionic liquid as a porogen and its applicat
In situ synthesis of twelve dialkyltartrate–boric acid complexes and two polyols–boric acid complexe
Preparation of Poly(1-dodecene-co-trimethylol propanetriacrylate-co-ethylene dimethacrylate) Monolit
Preparation of a Tetrazolyl Monolithic Column via the Combination of ATRP and Click Chemistry for th
In-situ polymerization of monolith based on poly(triallyl isocyanurate-co-trimethylolpropane triacry
Enantioseparation of Three b-Agonists Using Di-n-butyl D-Tartrate-Boric Acid Complex as Chiral Selec
An ion-pair principle for enantioseparations of basic analytes by nonaqueous capollary electrophores
A novel ionic liquid-based monolithic column and its application in the efficient separation of prot
期刊信息
位置：