中文摘要：

目的研究β-酪啡肽-7（β-CM-7）对小鼠酒精性肝损伤的防治作用。方法 60只昆明♂小鼠随机分为6组（每组10只）：对照组、模型组、护肝片组（0.3 g.kg-1）、β-CM-7高剂量组（灌胃剂量：2.0×10-1g.L-1）、β-CM-7中剂量组（灌胃剂量：2.0×10-2g.L-1）和β-CM-7低剂量组（灌胃剂量：2.0×10-3g.L-1）,除对照组外均采用梯度酒精灌胃的方法建立酒精性肝损伤动物模型,同时除模型组外各组分别给予药物治疗12周。观察用药前后各组小鼠生化指标血清丙氨酸转氨酶（ALT）、天冬氨酸转氨酶（AST）、甘油三酯（TG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）和肝组织匀浆中超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-Px）、丙二醛（MDA）水平的变化。结果β-CM-7高剂量组能够明显降低酒精性肝损伤小鼠血清中ALT、AST、TG、LDL-C水平（P〈0.05或P〈0.01）,提高血清HDL-C的含量,减少肝组织匀浆的MDA含量（P〈0.05或P〈0.01）,升高肝匀浆SOD,GSH-Px的水平（P〈0.05或P〈0.01）。结论β-酪啡肽-7对小鼠酒精性肝损伤有防治作用,可能与其调节脂质代谢,抗脂质过氧化

英文摘要：

Aim To investigate the protective effect of beta-casomorphin on alcohol-induced liver injury. Methods The paper studied alcohol-induced liver injury model in mice. Sixty mice were randomly divided into six groups, namely, control group, model group, huganpian group, beta-casomorphin low dose group, beta-casomorphin medium dose group and beta-casomorphin high dose group. Every group was respectively treated for 12 weeks with beta-casomorphin or huganpian control group accordingly except control group and model group. The biochemical indexes including the activities of AST, ALT , and the contents of TG, TC,LDL-C, HDL-C in serum, SOD, GSH-PX, and MDA in liver were examined. Results beta-casomorphin high dose could remarkably resist the increase of ALT, AST and the contents of TG, TC, LDL-C in mouse serum （ P 〈 0.05,P 〈 0.01 ）, decrease MDA level （ P 〈 0.05, P 〈0.01 ）,and improve SOD activity and GSH-Px level （P 〈 0. 05, P 〈 0. 01 ）. Conclusion beta-casomorphin can protect liver from alcoholic damage efficiently possibly by improving antioxidation.