中文摘要：

现在的学习试图定义 postsynaptic 的角色在多巴胺(DA ) 的规定的密度(PSD )-95 受体功能。我们发现 PSD-95 身体上在 co-transfected HEK-293 房间与 D1 或 D2 DA 受体联系。DA 受体的刺激以一种时间依赖者方式改变了在 D1 受体和 PSD-95 之间的协会。功能的试金显示 PSD-95 合作表示没影响 D1 刺激受体的营地生产， Gs 蛋白质激活或受体不敏感性。然而， PSD-95 由支持受体再循环加速了使内在化的膜受体的恢复，因此导致使内在化的 D1 受体的提高的促进感受性。我们的结果提供新奇机制因为调整再循环那的 DA 受体可以在 postsynaptic DA 功能的调整和 synaptic neuroplasticity 起一个重要作用。

英文摘要：

The present study aims to define the role of postsynaptic density （PSD）-95 in the regulation of dopamine （DA） receptor function. We found that PSD-95 physically associates with either D1 or D2 DA receptors in co-transfected HEK-293 cells. Stimulation of DA receptors altered the association between D1 receptor and PSD-95 in a time-depen- dent manner. Functional assays indicated that PSD-95 co-expression did not affect DI receptor-stimulated cAMP pro- duction, Gs-protein activation or receptor desensitization. However, PSD-95 accelerated the recovery of internalized membrane receptors by promoting receptor recycling, thus resulting in enhanced resensitization of internalized D1 receptors. Our results provide a novel mechanism for regulating DA receptor recycling that may play an important role in postsynaptic DA functional modulation and synaptic neuroplasticity.