中文摘要：

通过对模型进行分块,引入边界模型的D-最优设计,寻找到整个模型的D-最优,并根据异方差的特点讨论了两种情况异方差可加混料模型的D-最优设计.

英文摘要：

Based on the model block,the paper introduced the boundary model of D-optimal design,found the entire model of D-optimal and according to the characteristics of heteroscedasticity discussed the two kinds of additive mixing of heteroscedastic model D-optimal design.