目的初步探讨绝经后妇女骨密度与血红蛋白、血小板的相关性。方法随机选择319例福州常住汉族绝经后妇女,分为骨质疏松组147例,非骨质疏松组172例,双能X线骨密度仪测定腰椎、股骨颈、大转子和Ward’s区骨密度,SPSS18.0统计软件分析血红蛋白、血小板与不同部位骨密度的关系。结果 (1)与非骨质疏松组相比,骨质疏松组患者的血红蛋白含量更高(z=-3.099,P=0.002),血小板计数更多(z=-3.436,P=0.001)。(2)校正年龄、体重指数和绝经年限后,血小板与腰椎、大转子骨密度呈负相关(r1=-0.189,P1=0.001;r2=-0.146,P2=0.009);血红蛋白与腰椎、大转子骨密度也呈负相关(r1=-0.133,P1=0.018;r2=-0.200,P2=0.000)。(3)多元逐步回归分析显示,血红蛋白与大转子骨密度呈负相关(β=-0.183,P=0.000);血小板与腰椎骨密度呈负相关(β=-0.182,P=0.001)。结论绝经后妇女低骨量的发生与血红蛋白、血小板均存在负相关,鉴于与当前部分结果并不一致,故仍需进一步深入探究。
Objective To investigate the relationship between bone mineral density( BMD),hemoglobin( HGB),and platelet( PLT) in postmenopausal women. Methods A total of 319 postmenopausal Han women,who lived in Fuzhou,were randomly selected and divided into osteoporosis group( OP group,147 cases) and non-osteoporosis group( NOP group,172 cases). BMD of the lumbar vertebrae,the femoral neck,the greater trochanter,and the Ward’s area was detected using dual energy X-ray absorptiometry. The correlation between BMD of different parts,HGB,and PLT was analyzed using a SPSS 18. 0 statistical software. Results Compared with those in the NOP group,the hemoglobin level( z =- 3. 099,P = 3. 099) and platelet count( z=- 3. 436,P = 0. 001) in OP group were higher. After adjusting for age,body mass index( BMI),and duration of menopause,PLT was negatively correlated with BMD of the lumbar vertebrae and the greater trochanter( r1=- 0. 189,P1= 0. 001; r2=-0. 146,P2= 0. 009). HGB was also negatively correlated with BMD of the lumbar vertebrae and the greater trochanter( r1=-0. 133,P1= 0. 018; r2=- 0. 200,P2= 0. 000). Multiple stepwise regression analysis showed that HGB was negatively correlated with BMD of the greater trochanter( β =- 0. 183,P = 0. 000). PLT was negatively correlated with BMD of the lumbar vertebrae( β =-0.182,P =0.001). Conclusion The occurrence of low bone mass in postmenopausal women is negatively correlated with HGB and PLT. This result is not consistent with several current results,therefore,further study is needed.