中文摘要：

目的研究β淀粉样蛋白（Aβ1-42）对胆碱能神经元ATP敏感钾离子（KATP）通道离子流的影响。方法原代培养出生24 h内的乳鼠皮层和海马胆碱能神经元,采用膜片钳全细胞记录技术记录Aβ1-42对单个胆碱能神经元KATP通道离子流的影响。结果与对照组比较,给予Aβ1-42后胆碱能神经元外向电流显著减少（P〈0.05）,再给予ATP敏感性钾通道开放剂二氮嗪后此减小的外向电流无显著变化（P〉0.05）。结论 Aβ1-42对神经元KATP通道具有抑制作用。

英文摘要：

Objective To study the effect of β-amyloid peptides（Aβ1-42） on the current of ATP-sensitive potassium（KATP） channels in cultured cortical and hippocampal cholinergic neurons in rats.Methods Cortical and hippocampal cholinergic neurons from neonatal rats less than 24 h after birth were primarily cultured.Membrane currents were measured using patch clamp whole cell recordings.Results Compared with the controls,the outward current of neurons significantly decreased after using Aβ1-42（P0.05）.and there was no obvious change after giving diazoxide,an opener of KATP channels（P0.05）.Conclusion Aβ1-42 inhibits the opening of KATP channels.