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基于系统生物学的多靶点及多组分药物研究的进展
  • 期刊名称：中国药学杂志
  • 时间：0
  • 页码：1121-1126
  • 语言：中文
  • 分类：R91[医药卫生—药学]
  • 作者机构：[1]解放军第二军医大学药学院,上海200433, [2]解放军后勤工程学院数学教研室,重庆400016
  • 相关基金：国家自然科学基金资助项目（10971227）;国家杰出青年基金资助项目（30725045）;科技部“重大新药创制”专项资助项目（2009ZX09311-001）
  • 相关项目：中药化学
作者： 张卫东|赵静|
关键词： 选择性药物, 多靶点药物, 多组分药物, 分子网络, 系统生物学
中文摘要：

目的综述当前基于系统生物学的多靶点、多组分药物研究的一些方向和进展。方法文献检索方法。结果当前药物发现的原则主要遵循＂一药,一靶,一病＂的理念,即设计能与疾病相关的某一关键靶标特异结合的化学实体。尽管过去几十年中大多数选择性药物都是通过这种方法获得的,但是许多药物却很难达到预期临床效果,或产生严重的毒副作用。近年来,系统生物学的研究揭示了分子网络调控与疾病之间高度的关联性,并显示了在系统层面发现靶向疾病相关网络的多靶点、多组分药物的可能性。本文通过相关文献,分析了选择性药物设计的缺陷,并综述了基于系统生物学的多靶点、多组分药物研究的一些方向和进展。结论将药物研究与系统生物学结合,在各种调控网络的背景中研究多个靶点之间的作用与联系,有可能系统地预测和解释药物的作用,发现影响药物有效性和安全性的因素,从而产生新的治疗复杂疾病的策略,并开发出新的多靶点及多组分药物。

同期刊论文项目
中药化学
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基于网络生物学的药物分子作用机理研究
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