中文摘要：

Obesogen是近年来肥胖病因研究的新观点和新成果,其将环境中存在的促进或诱发肥胖发生的某些环境污染物或人工合成物看作肥胖的重要病因之一,由于这一类物质在国内尚未获得统一的命名与概述,为此本文建议将这些化学物命名为环境诱胖剂。目前被确认的环境诱胖剂有双酚A、己烯雌酚、全氟烷基酸（PFOA）、有机氯、有机锡、邻苯二甲酸酯等二十多种（类）化学物或药物,其诱胖机制主要为改变脂质稳态平衡和脂肪储量,代谢机制的调定点,促进脂肪的积聚。环境诱胖剂普遍存在于食物、饮水、空气等生活、生产和娱乐环境中,无法达到零接触,因而在寻找更多的环境诱胖剂的同时,需要建立有效的控制措施,以尽量减少这些化学物的接触机会和接触水平,预防肥胖的发生。

英文摘要：

Identifying environmental or artificial chemicals as causes of obesity is a new idea or new finding on the etiology of obesity. This idea showed that some environmental pollutants or artificially synthesized chemicals were recognized as important causes of obesity or promoting the tendency of obesity, and were collectively named as obesogens. Now, some chemicals or therapeutic drugs have been confirmed as chemical obesogens, including bisphenol A, diethylstilbestrol, perfluoroalkyl acid （PFOA） , organic chlorine, organic tin, and phthalate. The underlying mechanisms of the action of obesogens were disrupting lipid homeostasis and the storage of fat, changing the set-point of metabolic system, and finally promoting the accumulation of adipose tissue. However, owing to the universal existence of chemical obesogens in the environment of our daily life, and the exposure to these chemicals could not be completely avoided, minimizing the opportunities and levels of being exposed to these chemicals might be the best way to prevent the development of obesity.