中文摘要：

This study examined the association of a common polymorphic allele(25G) of the low-density lipoprotein receptor-related protein1(LRP1) gene with myocardial infarction(MI).The genotypes of LRP1 25CG(rs35282763) were determined in 347 MI patients and 347 age-and sex-frequency-matched controls from an unrelated Chinese Han population.Factor Ⅷ(FⅧ) levels were measured in the MI patients and controls by chromogenic assay and enzyme-linked immunosor-bent assay(ELISA).The results showed that LRP1 25CG(rs35282763) genotype distribution did not differ significantly between patients(n=206 for 25CC,n=122 for 25CG) and controls(n=191 for 25CC,n=126 for 25CG;P>0.05).The 25G allele was not associated with a reduced risk of MI(P>0.05).Further stratifications for age,sex,and other cardiovascular risk factors did not affect the negative findings.It was concluded that the presence of the G allele at the 25CG(rs35282763) polymorphism of the LRP1 is not associated with a reduced risk of MI,and genotyping for LRP1 25CG(rs35282763) polymor-phism is not useful in assessing the individual risk of MI.

英文摘要：

This study examined the association of a common polymorphic allele（25G） of the low-density lipoprotein receptor-related protein1（LRP1） gene with myocardial infarction（MI）.The genotypes of LRP1 25CG（rs35282763） were determined in 347 MI patients and 347 age-and sex-frequency-matched controls from an unrelated Chinese Han population.Factor Ⅷ（FⅧ） levels were measured in the MI patients and controls by chromogenic assay and enzyme-linked immunosor-bent assay（ELISA）.The results showed that LRP1 25CG（rs35282763） genotype distribution did not differ significantly between patients（n=206 for 25CC,n=122 for 25CG） and controls（n=191 for 25CC,n=126 for 25CG;P0.05）.The 25G allele was not associated with a reduced risk of MI（P0.05）.Further stratifications for age,sex,and other cardiovascular risk factors did not affect the negative findings.It was concluded that the presence of the G allele at the 25CG（rs35282763） polymorphism of the LRP1 is not associated with a reduced risk of MI,and genotyping for LRP1 25CG（rs35282763） polymor-phism is not useful in assessing the individual risk of MI.