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Relationship between acquired deficiency of vitamin K-dependent clotting factors and hemorrhage
  • ISSN号：1672-0733 (Print)
  • 期刊名称：J Huazhong Univ Sci Technolog Med Sci
  • 时间：0
  • 页码：312-7
  • 分类：R55[医药卫生—血液循环系统疾病;医药卫生—临床医学;医药卫生—内科学]
  • 作者机构：[1]Institute of Hematology Union Hospital Tongji Medical College Huazhong University of Science and Technology Key Laboratory of Biological Targeted Therapy of Hubei Province
  • 相关基金：supported by grants from the Ministry of Health of China(No.[2007]353);; the National Natural Sciences Foundation of China (N0.30700332);; the National Outstanding Youth Foundation(No.30825018);; the National Basic Research Program(973 Program,No.2007CB935803)
  • 相关项目：血栓栓塞性疾病的临床与基础研究
作者： R. Yang|X. Zhang|W. Wei|M. Hong|Y. Yang|Y. Hu|
中文摘要：

This study examined the changes of activities of vitamin K-dependent clotting factors(VKDCF) under various pathological conditions and explored the relationship between acquired deficiency of VKDCFs and hemorrhage.Clinical data of 35 patients who were diagnosed as having acquired deficiency of VKDCF were retrospectively analyzed.Coagulation factors involved in the intrinsic and extrinsic pathways were detected in these patients and 41 control subjects.The results showed that the average activities of VKDCFs...

英文摘要：

This study examined the changes of activities of vitamin K-dependent clotting factors(VKDCF) under various pathological conditions and explored the relationship between acquired deficiency of VKDCFs and hemorrhage.Clinical data of 35 patients who were diagnosed as having acquired deficiency of VKDCF were retrospectively analyzed.Coagulation factors involved in the intrinsic and extrinsic pathways were detected in these patients and 41 control subjects.The results showed that the average activities of VKDCFs...

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