中文摘要：

annexin A2 的反常表示贡献癌症房间的转移和渗入。阐明 annexin A2 的反常表示的原因，西方的弄污，染色的 immunoproteomics 和 immunohistochemical 被执行从五个女志愿者分析在新鲜乳癌织物和它的邻近的正常的胸织物之间的差别 ubiquitinated 蛋白质。我们检测了在癌症组织是起来调整的 ubiquitinated 蛋白质，它被集体 spectrometry 进一步作为 annexin A2 识别。这些结果建议 annexin A2 的反常 ubiquitination 或降级可以在高水平导致 annexin A2 的存在，它可以进一步支持乳癌房间的转移和渗入。

英文摘要：

Abnormal expression of annexin A2 contributes to metastasis and infiltration of cancer cells. To elucidate the cause of abnormal expres- sion of annexin A2, Western blotting, immunoproteomics and immunohistochemical staining were performed to analyze differentially ubiquitinated proteins between fresh breast cancer tissue and its adjacent normal breast tissue from five female volunteers. We detected an ubiquitinated protein that was up-regulated in the cancer tissue, which was further identified as annexin A2 by mass spectrometry. These results suggest that abnormal ubiquitination and/or degradation of annexin A2 may lead to presence of annexin A2 at high level, which may further promote metastasis and infiltration of the breast cancer cells.