在细胞信号网络中丝裂原活化蛋白激酶(mitogen-activated protein kinase,MAPK)信号传递途径起着极为重要的作用,控制着细胞多种生理过程,如细胞生长、发育、分裂、死亡等.ERK是MAPK家族重要的成员,通过检测三倍体湘云鲫胚胎和成体组织中ERK1/2的表达情况,初步研究ERK在鱼类发育中的作用.蛋白免疫杂交结果显示ERK1/2在三倍体湘云鲫的胚胎发育各个时期和组织中均有较高的表达,该结果表明ERK在鱼类发育的过程中发挥重要的作用.
As a member of MAPK family, ERK1/2 involved in regulating the growth, development, mitosis and apoptosis of cells. The expression of ERK1/2 was detected in embryos and adult tissue of triploid fish. There existed high level of ERK1/2 in embryos and adult tissue of triploid fish. These results show that ERK1/2 may play important roles in the development of fish.