中文摘要：

长非编码RNA（long noncoding RNAs,lncRNAs）是一组长度〉200个核苷酸、缺少特异完整的开放阅读框、无蛋白质编码功能的RNA。研究显示,lncRNAs可参与表观遗传修饰,在肝癌的发生、发展、浸润和转移中发挥重要作用。此外,lncRNAs还可诱导肝癌对化疗药物产生耐药而导致化疗失败,给肝癌的治疗带来较大困难。本文就与肝癌有关的lncRNAs的特征、在肝癌中的作用及其分子机制等方面进行简要综述,为临床肝癌的基因诊断和治疗提供新的思路。

英文摘要：

Long noncoding RNAs（lncRNAs） is a group of RNAs,which are longer than 200 nucleotides without containing functional open reading frames and can not encode proteins.The studies indicate that lncRNAs can participate in the epigenetic modification,and play an important role in occurrence,development,invasion and metastasis of hepatic carcinoma.Moreover,lncRNAs can also induce the resistance to chemotherapy and result in the failure of chemotherapy,which brings out more difficulty for the treatment of hepatic carcinoma.This article reviews the characteristics of lncRNAs related with hepatic carcinoma as well as their functions and undelying molecular mechanism to provide new insights into genetic diagnosis and treatment of hepatic carcinoma in clinic.