中文摘要：

柱子翻译修正嘘在组成的异种染色质， genomicimprinting ，在激活的X染色体和基因 transcription.Histone demethylase 催化的染色质 regulation.Histone methylation 影响起一个重要作用离氨酸或 histones.Two 类型的精氨酸残余上的甲基组的移动嘘一 lysinedemethylases 被识别了，包括离氨酸特定的 demethylase 1 并且 Jumonji C ( JmjC )领域家庭蛋白质。这些嘘一 demethylases 涉及 geneexpression.Histone 修正的规定是一个动态过程，和不平衡嘘一 methylation 过时的人或物连接了到癌症。因此，嘘一 demethylases 可以为 anti-cancertherapy 代表一个新目标。

英文摘要：

The posttranslational modification of histones plays an important role in chromatin regulation. Histone methylation influences constitutive heterochromatin, genomic imprinting, X-chromosome inactivation and gene transcription. Histone demethylase catalyzes the removal of methyl groups on lysine or arginine residues of histones. Two kinds of histone lysine demethylases have been identified, including lysine specific demethylase I and Jumonji C （JmjC） domain family proteins. These histone demethylases are involved in the regulation of gene expression. Histone modification is a dynamic process, and the imbalance of histone methylation has been linked to cancers. Therefore, histone demethylases may represent a new target for anti-cancer therapy.