中文摘要：

目的探讨3种不同诊断方法诊断糖尿病肾病（DKD）的患病情况及其影响因素。方法将1 254例2型糖尿病患者纳入研究,根据尿微量白蛋白与肌酐比值（UACR）、估算肾小球滤过率（eGFR）、UACR联合eGFR 3种方法将其分为DKD组及单纯糖尿病组,计算3种方法 DKD的诊断比率,并比较3种方法下的2个分组的临床和生化特征,采用Logistic回归分析相关影响因素。结果UACR、eGFR、UACR联合eGFR 3种诊断方法的DKD诊断比率分别为33.9%、15.9%、38.7%。3种诊断方法下DKD组的年龄、病程、收缩压水平均高于单纯糖尿病组（P均〈0.05）。Logistic回归结果显示,采用UACR诊断方法时,年龄、BMI、收缩压、病程、直接胆红素是DKD的相关因素;采用eGFR诊断方法时,BMI、收缩压、病程、血红蛋白、白蛋白是DKD的相关因素;采用UACR联合eGFR诊断方法时,年龄、病程、收缩压、BMI、甘油三酯、直接胆红素、血红蛋白、白蛋白是DKD的相关因素（P均〈0.05）。结论与单独采用UACR或eGFR相比,采用UACR联合eGFR时的DKD诊断比率最高,可提高早期检出率;采用该方法时,年龄、病程、收缩压、BMI、甘油三酯等是DKD的相关因素。

英文摘要：

Objective To investigate the incidence and related factors of diabetic kidney disease （DKD） diagnosed by three methods.Methods A total of 1 254 patients with type 2 diabetes mellitus were included in this study.All patients were divided into the DKD and diabetes mellitus alone groups according to the urinary albumin/creatinine ratio （UACR）, estimated glomerular filtration rate （eGFR） or UACR combined with eGFR.The diagnostic rate of DKD using three methods was calculated.Clinical and biochemical characteristics were statistically compared between two groups.The related factors were identified by Logistic regression analysis. Results The diagnostic rates of DKD for UACR, eGFR and UACR in combination with eGFR were 33.9%, 15.9% and 38.7%, respectively. For three diagnostic procedures, age, course of diseases and systolic blood pressure in the DKD group were significantly higher compared with the diabetes mellitus alone group （all P 〈0.05）. Logistic regression analysis revealed that age, body mass index （BMI）, systolic blood pressure,course of diseases and conjugated bilirubin were the related factors of DKD for the diagnostic method of UACR （all P 〈0.05）;In terms of eGFR diagnostic method, BMI, systolic blood pressure,course of diseases hemoglobin and albumin were the related factors of DKD. For the diagnostic method of UACR combined with eGFR, age, course of diseases, systolic blood pressure, BMI, triglyceride, conjugated bilirubin, hemoglobin and albumin were the related factors of DKD （all P 〈0.05）. Conclusions Compared with UACR or eGFR alone, UACR in combination with eGFR yields a higher early diagnostic rate. Age, course of diseases, systolic blood pressure, BMI, triglyceride, conjugated bilirubin, hemoglobin and albumin are the related factors of DKD.