中文摘要：

当钥匙走，一条有效、可行的合成途径与 chalcones 和随后的环合的减小从代替的 benzaldehyde 为一连串的新 flavane 衍生物的合成被开发。产品的纯净和结构被元素的分析和它的红外， 1H 和 13C NMR，和集体系列的联合证实。这些合成混合物为黄质 oxidase (XO ) 被测试对 Candida albicans 的抑制和抗真菌的行动， Cryptococcus neoformans，曲霉属菌 sp。并且 Trichophyton rubrum。7-Hydrazinocarbonylmethoxy-4-methoxyflavane (9 ) 与 IC50=76.4 mol/L，和抗真菌的化合物是的大多数有势力被发现是大多数 XO 禁止有对 Trichophyton rubrum 的最小的抑制集中 MIC8 g/mL 的 4-hydrazinocarbonylmethoxyflavane (12 ) 。

英文摘要：

An efficient and feasible synthetic approach was developed for the synthesis of an array of new flavane derivafives from the substituted benzaldehyde with the reduction of chalcones and subsequent cyclization as the key steps. The purity and structure of the products were confirmed by the elemental analysis and a combination of its IR, ^1H and ^13C NMR, and mass spectra. These synthetic compounds were tested for xanthine oxidase （XO） inhibitions and antifungal actions against Candida albicans, Cryptococcus neoformans, Aspergillus sp. and Trichophyton rubrum. 7-Hydrazinocarbonylmethoxy-4＇-methoxyflavane （9） was found to be the most XO inhibitory with IC50=76.4 μmol/L, and the most potent antifungal compound was 4＇-hydrazinocarbonylmethoxyflavane （12） with minimal inhibition concentration MIC=8 μg/mL against Trichophyton rubrum.