中文摘要：

首先通过改进的Hummers法制备了氧化石墨烯（G0），然后通过酰胺化反应将端基为氨基的六臀浆乙二醇（PEG）连接到氧化石墨烯的表面，以改善其水溶性和生物相容性．原子力显微镜（AFM）数据表明所制备的GO—PEG的尺、川、r250rim，稳定性试验证明GO—PEG在水和PBS缓冲液中可以很好地分散．利用制备的GO—PEG作为药物载体．通过物理共混的方法负载了疏水性抗肿瘤药物——毛萼乙素．紫外光谱法测得载药率为18．8％．选择肺癌细胞A549和乳腺癌细胞MCF一7对载药体系的细胞毒性进行了研究，结果表明即使在高达100mg／L的浓度下培养48h，GO—PEG载体对两种细胞仍然具有很小的毒性（相对细胞存活率〉85％），而通过载体负载毛萼乙素后的疗效有所增强，对癌细胞只有

英文摘要：

Graphene oxide （GO） was firstly prepared by modified Hummers method. In order to improve its water solubility and biocompatibility, 6-arm PEG was grafted to GO via a facile amidation reaction. The size of obtained GO-PEG was less than 250 nm. Stability test indicated the good dispersibility of GO-PEG in water and PBS buffer. Furthermore, eriocalyxin B, a widely used cancer chemotherapy drug, is adsorbed onto GO-PEG via physical blending with a drug loading ratio of 18.8% obtained by UV spectrum. Lung cancer cell A549 and breast cancer cell MCF-7 were selected to study the cytotoxicity ot GO-PEG/eriocalyxin B, GO-PEG, and free eriocalyxin B. The results demonstrated that GO-PEG nano-carrier possessed low toxicity （relative cell viability〉85%）, even cultivated for 48 h at a relatively high concentration of 100 mg/L. Compared to pure drug, GO-PEG/eriocalyxin B nanocarrier shows higher cytotoxicity in A549 and MCF-7 cells.