中文摘要：

目的探索中药配伍对中药复方药效成分药动学的影响。方法采用反相高效液相色谱法测定延胡索乙素的血药浓度，非房室模型拟合药动学参数，统计学处理采用t检验法。结果延胡索提取物组和延胡索白芷提取物组的主要药动学参数：pmax分别为（0．484±0．30）和（0．853±0．52）mg·L^-1，AUC0-∞分别为（1．822±1．0）和（5．542±3．8）mg·h·L^-1，tmax分别为（1．06±0．83）和（1．88＋1．6）h，两组药动学参数的差异具有显著性统计学意义（P〈0．05）。结论延胡索与白芷配伍对延胡索乙素的药动学特征有显著影响，提示该配伍可能是导致延胡索乙素的药动学特征变化的原因。

英文摘要：

OBJECTIVE To investigate the influence of Chinese herb prescription Yanhusuo-Baizhi on pharmacokinetic properties of tetrahydropalmatine（THP） in dogs. METHODS The concentrations of tetrahydropalmatine in dog plasma were determined by HPLC method. The pharmacokinetic parameters were calculated using non-compartmental model and t test was used for statistical analysis. RESULTS The mean ,Omax, AUC0-∞ and tmax of THP administrated with Yanhusuo-Baizhi extract were （0.853±0.52）mg.Ll, （5.542±3.8）mg·h ·L^-1 and （1.88±1.6）h, significantly higher （P〈0.05） than those administrated with Rhizoma Corydalis extract. CONCLUSION There was significant influence of Yanhusuo-Baizhi prescription on pharmacokinetics of THP in dogs, suggesting the compatibility in drug combination of Yanhusuo-Baizhi.