中文摘要：

目的：总结分析2例原发性血小板增多症患者妊娠期及围产期的治疗过程，并进行相关文献复习。方法评估2例妊娠原发性血小板增多症患者，根据患者危险度分层，在妊娠期及围产期分别给予个体化治疗。结果1例高危患者妊娠期全程给予低分子肝素及干扰素α-2 b 治疗，另1例低危患者妊娠期全程给予阿司匹林及干扰素α-2 b 治疗；2例患者均安全娩出胎儿，产后12小时应用低分子肝素至围产期结束。结论原发性血小板增多患者妊娠期及围产期极易出现各种并发症，需在血液科和产科医生的合作下，根据患者危险度分层给予全程个体化治疗、合理用药。

英文摘要：

Objective To present the treatment of two essential thrombocythemia （ET） patients during gestation period and perinatal period, and analyze the rational medication. Methods Evaluated two ET patients, and individualized ther-apies were given during the gestation period and perinatal period according to the risk stratification. Results To the high risk patient, low molecular weight heparin （LMWH） and interferon α-2 b were applied during the whole ges-tation period; to the low risk patient, aspirin and interferon α-2 b were applied during the whole gestation period. Both patients delivered the fetus successfully, and LMWH was used from 12 hours to 6 weeks after delivery. Conclu-sion ET patients during gestation period and perinatal period are at high risk of complications. Evaluation of the prog-nosis, individualized treatment and rational drug use is required, by the cooperation of hematologists and obstetrists.