中文摘要：

目的：探讨治疗前血清乳酸脱氢酶（LDH）与血清碱性磷酸酶（ALP）水平对鼻咽癌患者预后的影响。方法：收集2006-04-2008-10期间在我院初治的339例鼻咽癌患者的年龄、性别、T分期、N分期、临床分期、放疗方式、放疗剂量、治疗前血清LDH水平、治疗前血清ALP水平等资料,应用单因素和多因素分析的统计学方法分析其与鼻咽癌患者预后的相关性。结果：本组病例1、3、5年生存率分别为97.8%、85.0%、78.5%,单因素分析显示年龄、临床分期、治疗前血清LDH与患者预后相关（P〈0.05）。多因素分析显示年龄、临床分期及治疗前血清LDH水平是影响患者预后的独立因素。结论：年龄大于50岁、Ⅲ＋Ⅳ期及治疗前血清LDH升高是鼻咽癌患者复发和死亡的独立危险因素。

英文摘要：

Objective：To investigate the effects of serum lactate dehydrogenase（LDH）and serum alkaline phosphatase（ALP）levels on the prognosis of patients with nasopharyngeal carcinoma（NPC）before treatment.Method：Three hundred and thirty nine NPC cases,who were firstly treated in our hospital from April 2006 to October 2008,were enrolled in our study.Association of overall survival（OS）rate and disease-free survival（DFS）rate with clinical characteristics（age,gender,Tclassification,Nclassification,Clinicalstage,radiotherapymethods,radiotherapydose,the levels of pretreatment serumLDH）were evaluated using univariate and multivariate analysis methods.Result：Univariate analysis showed that age,clinical stage,pretreatment LDHlevel were significantly associated with OS and DFS of NPC.And multivariate analysis revealed that age,clinical stage and pretreatment LDH level were independent factors for OS and DFS.Conclusion：age,clinical stage and the levels of pretreatment LDH level may be independent prognostic factorsto predict recurrence and death of NPC.