中文摘要：

目的探讨甲状腺癌合并乳腺癌患者的临床特点。方法收集1985年5月—2015年8月广西医科大学附属肿瘤医院诊断为甲状腺癌合并乳腺癌患者17例,并对其临床资料进行回顾性分析。结果 17例甲状腺癌合并乳腺癌患者均为女性,有肿瘤家族史4例。17例甲状腺癌病理均确诊为乳头状癌;乳腺癌病理确诊为浸润性导管癌者13例,导管内癌4例。首发癌为甲状腺癌患者6例,平均发病年龄为34岁,次发乳腺癌平均发病年龄为44.3岁,首发到第二癌确诊平均间隔时间为124.5个月。首发癌为乳腺癌患者11例,平均发病年龄为41.2岁,次发甲状腺癌平均发病年龄为44.7岁,平均间隔时间为53.8个月。6例甲状腺癌首发患者均接受甲状腺癌根治手术,手术后均出现甲状腺功能低下,均予以左旋甲状腺素片治疗。11例乳腺癌首发患者行行单纯乳腺癌根治术1例,根治术后化疗5例,根治术后放化疗3例,保留乳房手术后放疗1例,姑息性手术后化疗及内分泌治疗1例。结论甲状腺癌和乳腺癌相互之间的发病关系密切,病理以甲状腺乳头状癌和乳腺浸润性导管癌为主,对甲状腺癌患者或乳腺癌患者治疗后随访中应该常规行甲状腺和乳腺的相关检查。

英文摘要：

Objective To explore the clinical characteristics of multiple primary malignants of thyroid cancer and breast cancer. Methods Clinical data of 17 patients of thyroid cancer combined with breast cancer who were diagnosed in authors hospital from May 1985 to Auguest 2015 were retrospectively analyzed. Results All of 17 cases were women, 4 cases have family history of malignant neoplasm. All of the cases were pathologically diagnosed as papillary carcinoma; with regard to breast cancer, 13 cases were diagnosed as invasive ductal carcinoma, 4 cases as intraductal carcinoma. Six cases were with thyroid carcinoma as first primary malignancy, with median age at diagnosed being 34 years. And their median age experiencing breast cancer was 44. 3 years. The mean interval time between the two cancers was 124.5 months. The other 11 cases were with breast cancer as first tumor, and the mean age when diagnosed was 41.2 years. Their median age at diagnosed of thyroid cancer was 44.7 years, and the mean interval time between these 2 cancers was 53.8 months. Six cases with thyroid carcinoma as first tumor underwent radical surgery, and had administration of Levothyroxine. And among those 11 cases with breast cancer as first tumor, 1 case underwent radical surgery, 5 cases radical surgery plus postoperative chemotherapy, 3 cases radical surgery plus postoperative chemo＇radiotherapy, 1 case received breast- conserving surgery plus postoperative radio-therapy, I case received palliative operation plus postoperative chemotherapy and endocrine therapy. Conclusions There is a close relationship between thyroid cancer and breast cancer, with their pathology types being mainly thyroid papillary carcinoma and breast invasive ductal carcinoma, during the follow- up after treatment, the patients should routinely have their thyroid and mammary gland examined.