中文摘要：

目的：探讨急性脑梗死与感染及炎症反应之间的关系，以期提高临床诊治水平。方法选取2010年2月－2014年1月36例急性脑梗死患者为研究对象，另外选取同时期的31例健康体检患者为对照组，观察急性脑梗死患者的感染率，比较两组在C‐反应蛋白（CRP）、补体C3、C4、白细胞介素‐1（IL‐1）、白细胞介素‐6（IL‐6）、肿瘤坏死因子‐α（T N F‐α）等指标的差异性。结果36例患者中感染5例，感染率为13．89％，其中呼吸道感染占60．00％，而在实验室检查中血沉、白细胞、D二聚体以升高为主，其中急性脑梗死病情越重，则CRP含量越高；急性脑梗死组和对照组在CRP、IL‐1、IL‐6、TNF‐α指标比较差异有统计学意义（P＜0．05），而在补体C3、C4上比较差异无统计学意义。结论感染是形成急性脑梗死危险因素之一，而炎症反应参与了急性脑梗死的发生发展。

英文摘要：

OBJECTIVE To investigate the correlation between the acute cerebral infarction and infections and in‐flammatory response so as to improve the level of clinical treatment and diagnosis .METHODS A total of 36 pa‐tients with acute cerebral infarction who were treated from Feb 2010 to Jan 2014 were recruited as the study ob‐jects ,meanwhile ,31 healthy people who underwent physical examinations were chosen as the control group .The incidence of infections in the patients with cerebral infarction was observed ,and the levels of C‐reactive protein （CRP） ,complement C3 ,C4 ,interleukin‐1 （IL‐1） ,interleukin‐6 （IL‐6） ,and tumor necrosis factor‐α（TNF‐α） were determined and compared between the two groups .RESULTS The infections occurred in 5 of 36 patients , with the infection rate of 13 .89% ,and the patients with respiratory tract infections accounted for 60 .00% .The la‐boratory examination was characterized by the elevation of erythrocyte sedimentation rate ,white blood cells ,and D‐dimer .The severer the condition of acute cerebral infarction ,the higher the content of CRP was .There was sig‐nificant difference in the CRP ,IL‐1 ,IL‐6 ,or TNF‐αbetween the acute cerebral infarction group and the control group （P〈0 .05） ,however ,there was no significant difference in the C3 or C4 .CONCLUSION The infection is one of the risk factors for the acute cerebral infarction ,and the inflammatory response may involve in the patho‐genesis of the acute cerebral infarction .