中文摘要：

背景与目的：研究中药香加皮水提取物（cortex periplocae extract,CPE）的体内、外抗肿瘤效果。材料与方法：采用MTT法和克隆形成实验,检测CPE对6种不同组织来源肿瘤细胞（K562、BGC-823、TE-13、SMMC-7721、MCF-7和HeLa）增殖反应的影响;将CPE灌胃给予S180和colon26荷瘤小鼠,观察其对肿瘤形成及小鼠生存期的影响。结果：CPE对6种不同肿瘤细胞株均有明显的抑制作用（P〈0.05）,其中对K562,BGC-823,TE-13的抑制作用量效关系明显（r分别为0.89、0.71和0.72,P值均〈0.05）。将CPE灌胃S180或colon26荷瘤小鼠,可明显抑制肿瘤在体内的生长,并可明显延长荷瘤小鼠的生存期（P〈0.05）。结论：CPE对6种不同组织来源的肿瘤细胞均具有抑制作用,可明显抑制荷瘤小鼠肿瘤的生长,延长荷瘤小鼠寿命。香加皮作为抗肿瘤药物有待进一步开发研究。

英文摘要：

BACKGROUND ＆ AIM： To investigate the anti-tumor activity of cortex periplocae extract （CPE） on the proliferation of tumor cells in vitro and in vivo. MATERIALS AND METHODS： The suppressive effect of CPE on the proliferation of different human tumor cells was evaluated by using MTT assay and colony formation test. Its in vivo anti-neoplastic action was studied by observing its effect on the weight of tumors in colon 26 tumor beating mice and the life spans of S180 tumor bearing mice. RESULTS： CPE had a definite inhibitory effect on proliferation of the human tumor cell lines in vitro, most prominent to K562, BGC-823 and TE-13 tuner cells （P〈0.01）. It also had an obvious inhibition on colony formation of the above tumor cell lines in vitro （P 〈 0.05） It showed obvious inhibition on the growth of tumor in colon 26 bearing mice and prolonged the life span of S180 bearing mice in vivo. CONCLUSION： CPE could inhibit the growth of several tumor cells in vitro and in vivo effectively. For CPE to be used as an anti-tumor agent awaits further studies.