中文摘要：

在超声域以内基于包含的 microbubbles 的一个理论运动方程， microbubbles 的次谐波描述被一台计算机最佳地设计并且分析帮助设计系统。microbubbles 的次谐波反应上的尺寸，壳弹性和声学的压力的效果理论上被计算为非破坏性的次谐波成像获得最佳的参数。另外，有不同的壳弹性的 microbubbles 被准备，并且他们的次谐波回答在理论计算和好次谐波改进能被与 3m 的吝啬的尺寸使用包含的 microbubbles 获得的声学的测量表演的 vitro.The 结果被测量，它与 material.It 也被显示出的壳的合适的比率从表面活化剂答案被准备最好的操作声学的压力是为非破坏性的次谐波 ima 的 200～400 kPa

英文摘要：

Based on a theoretical motion equation of encapsulated microbubbles within an ultrasound field, the subharmonic characterizations of microbubbles are optimally designed and analyzed by a computer aided design system. The effects of size, shell elasticity and acoustic pressure on subharmonic response of microbubbles are calculated theoretically to obtain the optimal parameters for nondestructive subharmonic imaging. In addition, microbubbles with different shell elasticity are prepared, and their subharmonic responses are measured in vitro. The results of theoretical calculation and acoustic measurement show that good subharmonic enhancement can be obtained by using the encapsulated microbubbles with the mean size of 3 μm, which were prepared from the surfactant solution with the proper ratio of shell material. It is also shown that the best operating acoustic pressure is 200 to 400 kPa for nondestructive subharmonic imaging based on such kind of microbubbles.