中文摘要：

磷脂是细胞膜的主要组分,有非常重要的生理功能,与人类健康、疾病密切相关。因此,有必要对生物体内磷脂化合物进行全面的分析,深入研究磷脂在疾病发生发展过程中的生物功能。磷脂组学是通过全面的定性与定量分析磷脂化合物解决现有生物学问题的研究模式。磷脂分析检测技术是实现磷脂组学研究的关键,包括样品前处理、分离、定性与定量分析和组学数据挖掘等。本文综述了磷脂组学研究中的分析检测技术,为发展快速、稳定、可靠、高灵敏、高分辨、高通量的磷脂检测平台技术提供参考。磷脂组学与其他组学的整合研究将促进生命分析化学的进一步发展。

英文摘要：

Phospholipids, the principal constituents of cell membranes, have very important physiological functions and is closely related to human health and diseases. Therefore, comprehensive analysis of phospholipids is essential to enhance our understanding of function of phospholipids in disease process. Phospholipidomics is a phospholipids-targeted metabolomic approach which focuses on comprehensive qualitation and quantitation of phospholipids in biological system. Phospholipidomics study is carried out by the analysis and detection technologies involved in sample preparation, separation, qualitation and quantitation and data mining. In this paper, analysis and detection technologies for phospholipidomics are reviewed, providing a valuable reference for developing fast, stable, reliable, high sensitivity, high resolution, and high throughput platform technologies for phospholipidomics. The integrated investigation of phospholipidomics and other omics are proposed to promote the further development of analytical bioscience.